Tim H Brümmendorf Selected Research

bosutinib

6/2022	Safety profile of bosutinib in Japanese versus non-Japanese patients with chronic myeloid leukemia: a pooled analysis.
1/2022	Bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia: final results from the BFORE trial.
12/2021	Efficacy and safety following bosutinib dose reduction in patients with Philadelphia chromosome‒positive leukemias.
7/2021	Efficacy and safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the Asian subpopulation of the phase 3 BFORE trial.
6/2021	Long-term cardiac, vascular, hypertension, and effusion safety of bosutinib in patients with Philadelphia chromosome-positive leukemia resistant or intolerant to prior therapy.
6/2020	Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia.
1/2020	Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study.
6/2019	Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia.
1/2018	Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial.
1/2018	Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor.

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Tim H Brümmendorf Research Topics

Disease

56	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2022 - 01/2003
54	Neoplasms (Cancer) 10/2022 - 01/2004
25	Leukemia 12/2021 - 01/2004
15	Philadelphia Chromosome 12/2021 - 01/2004
10	Blast Crisis (Blast Phase) 12/2021 - 04/2008
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 08/2011
9	Disease Progression 12/2021 - 03/2005
6	Infections 08/2021 - 06/2015
6	Primary Myelofibrosis (Myelosclerosis) 08/2021 - 12/2014
6	Breast Neoplasms (Breast Cancer) 01/2018 - 01/2004
5	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2021 - 09/2015
5	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 01/2021 - 08/2012
5	Diarrhea 01/2018 - 10/2011
5	Prostatic Neoplasms (Prostate Cancer) 04/2015 - 06/2008
4	Neutropenia 01/2015 - 03/2011
3	COVID-19 08/2021 - 01/2020
3	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021 - 03/2016
3	Bone Marrow Failure Disorders 01/2021 - 07/2012
3	Fever (Fevers) 11/2017 - 10/2014
3	Hematologic Neoplasms (Hematological Malignancy) 07/2017 - 08/2012
3	Edema (Dropsy) 10/2014 - 06/2006
2	Exanthema (Rash) 06/2022 - 04/2012
2	Hodgkin Disease (Hodgkin's Disease) 05/2022 - 10/2016
2	Aplastic Anemia (Anemia, Hypoplastic) 01/2022 - 07/2012
2	Hypertension (High Blood Pressure) 08/2021 - 06/2021
2	Fibrosis (Cirrhosis) 01/2021 - 01/2021
2	Polycythemia Vera 01/2021 - 01/2019
2	Hematologic Diseases (Blood Diseases) 01/2021 - 01/2018
2	Pneumonia (Pneumonitis) 11/2020 - 09/2015
2	Chronic Disease (Chronic Diseases) 07/2019 - 01/2011
2	Testicular Neoplasms (Testicular Cancer) 01/2019 - 12/2010
2	Communicable Diseases (Infectious Diseases) 01/2017 - 11/2012
2	Carcinogenesis 04/2016 - 08/2011
2	Hepatocellular Carcinoma (Hepatoma) 04/2013 - 01/2007
2	Neoplasm Metastasis (Metastasis) 09/2012 - 01/2010
2	Chromosome Aberrations (Chromosome Abnormalities) 09/2011 - 10/2007
2	Adenocarcinoma 09/2010 - 06/2009
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 09/2005 - 06/2005
1	Anemia 03/2022
1	Pure Red-Cell Aplasia 09/2021
1	Thrombosis (Thrombus) 08/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 06/2021
1	Werner Syndrome (Werner's Syndrome) 01/2021
1	Mast-Cell Leukemia (Leukemia, Mast Cell) 01/2021
1	Revesz Debuse syndrome 01/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Hoyeraal Hreidarsson syndrome 01/2021
1	Systemic Mastocytosis 01/2021

Drug/Important Bio-Agent (IBA)

37	Imatinib Mesylate (Gleevec)FDA Link 01/2022 - 01/2003
29	Tyrosine Kinase InhibitorsIBA 11/2022 - 01/2004
27	bosutinibIBA 06/2022 - 10/2011
11	Telomerase (Telomerase Reverse Transcriptase)IBA 06/2021 - 03/2005
8	Dasatinib (BMS 354825)FDA Link 12/2021 - 05/2011
8	Biomarkers (Surrogate Marker)IBA 08/2021 - 04/2013
6	nilotinib FDA Link 12/2021 - 04/2012
6	Pharmaceutical PreparationsIBA 01/2021 - 06/2005
6	Phosphotransferases (Kinase)IBA 11/2020 - 01/2010
6	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 09/2010
6	bcr-abl Fusion ProteinsIBA 05/2017 - 01/2004
5	AntigensIBA 01/2019 - 12/2010
5	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2004
3	Immune Checkpoint InhibitorsIBA 01/2021 - 01/2021
3	AndrogensIBA 01/2021 - 07/2012
3	EnzymesIBA 01/2021 - 09/2012
3	Interferon-alpha (Interferon Alfa)IBA 01/2019 - 06/2005
3	ProteomeIBA 01/2014 - 04/2012
3	Aurora KinasesIBA 09/2012 - 12/2008
3	danusertibIBA 09/2012 - 04/2008
2	Messenger RNA (mRNA)IBA 01/2022 - 08/2021
2	Thrombopoietin ReceptorsIBA 11/2021 - 01/2016
2	CalreticulinIBA 11/2021 - 01/2016
2	Polychlorinated Biphenyls (PCBs)IBA 01/2021 - 01/2017
2	ruxolitinibIBA 11/2020 - 06/2015
2	Lenalidomide (CC 5013)FDA Link 06/2017 - 09/2015
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 11/2015 - 01/2007
2	CytokinesIBA 06/2015 - 08/2011
2	Cetuximab (Erbitux)FDA Link 10/2013 - 09/2010
2	Cisplatin (Platino)FDA LinkGeneric 10/2013 - 09/2006
2	Fluorouracil (Carac)FDA LinkGeneric 10/2013 - 09/2012
2	Peptide Initiation Factors (Initiation Factor)IBA 11/2012 - 02/2007
2	DNA (Deoxyribonucleic Acid)IBA 08/2011 - 01/2009
1	Nonsense Codon (Nonsense Mutation)IBA 03/2022
1	isocitric acid (isocitrate)IBA 01/2022
1	Lipocalin-2IBA 08/2021
1	Uric Acid (Urate)IBA 08/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 08/2021
1	tasquinimodIBA 01/2021
1	AlarminsIBA 01/2021
1	Inositol (Myoinositol)IBA 01/2021
1	tert-butylserineIBA 01/2021
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2021
1	Platelet Factor 4IBA 01/2021
1	Decitabine FDA Link 01/2021

Therapy/Procedure

39	Therapeutics 10/2022 - 02/2007
6	Drug Therapy (Chemotherapy) 05/2022 - 06/2006
4	Drug Tapering 12/2021 - 02/2014
3	Immunotherapy 01/2019 - 12/2010
2	Stem Cell Transplantation 01/2021 - 04/2009
1	Erythrocyte Transfusion 09/2021
1	Aftercare (After-Treatment) 06/2021